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Träfflista för sökning "WFRF:(Brun Arne) ;pers:(Brun Arne);pers:(Yancopoulou D)"

Search: WFRF:(Brun Arne) > Brun Arne > Yancopoulou D

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1.
  • Brown, J, et al. (author)
  • Frontotemporal dementia linked to chromosome 3
  • 2004
  • In: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 17:4, s. 274-276
  • Journal article (peer-reviewed)abstract
    • A large pedigree with autosomal dominant frontotemporal dementia has been identified. Positional cloning has linked the disease gene to the pericentromeric region of chromosome 3. Clinical, neuropsychological, imaging, pathological and molecular genetic data are presented. The genetic mutation responsible for the disease has not been identified.
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2.
  • Gydesen, S, et al. (author)
  • Chromosome 3 linked frontotemporal dementia (FTD-3)
  • 2002
  • In: Neurology. - 1526-632X. ; 59:10, s. 1585-1594
  • Journal article (peer-reviewed)abstract
    • Background: The authors have identified and studied a large kindred in which frontotemporal dementia (FTD) is inherited as an autosomal dominant trait. The trait has been mapped to the pericentromeric region of chromosome 3. Methods: The authors report on the clinical, neuroimaging, neuropsychological, and pathologic features in this unique pedigree collected during 17 years of study. Results: Twenty-two individuals in three generations have been affected; the age at onset varies between 46 and 65 years. The disease presents with a predominantly frontal lobe syndrome but there is also evidence for temporal and dominant parietal lobe dysfunction. Late in the illness individuals develop a florid motor syndrome with pyramidal and extrapyramidal features. Structural imaging reveals generalized cerebral atrophy; H-2 O-15-PET scanning in two individuals relatively early and late in the disease shows a striking global reduction in cerebral blood flow affecting all lobes. On macroscopic pathologic examination, there is generalized cerebral atrophy affecting the frontal lobes preferentially. Microscopically, there is neuronal loss and gliosis without specific histopathologic features. Conclusions: FTD-3 shares clinical and pathologic features with other forms of FTD and fulfills international consensus criteria for FTD. There is involvement of the parietal lobes clinically, radiologically, and pathologically in FTD-3 in contrast to some forms of FTD. This more diffuse involvement of the cerebral cortex leads to a distinctive, global pattern of reduced blood flow on PET scanning.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Gade, A. (2)
Brun, Arne (2)Undo refine
Collinge, J (2)
Johannsen, P. (2)
Gydesen, S (2)
Chakrabarti, L (2)
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Thusgaard, T (2)
Brown, J. (1)
Sorensen, A (1)
Sorensen, SA (1)
Brown, JM (1)
Spillantini, MG (1)
Skibinski, G (1)
Spillantini, M (1)
Fisher, E (1)
ROSSOR, M (1)
Grove, A (1)
Fisher, EMC (1)
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University
Lund University (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

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